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PDF fileFederal policymakers have an active and enduring interest in STEM education and the topic is frequently raised in federal science education workforce national security and immigration policy debates For example more than 200 bills containing the term “science education” were introduced between the 100 th and 110th congresses The United States is widely believed to.

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Here we a present a structural characterization of all 12 possible mismatches captured at the growing primer terminus in the active site of a polymerase Our observations suggest four mechanisms that lead to mismatchinduced stalling of the polymerase Furthermore we have observed the effects of extending a mismatch up to six base pairs from the primer.

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